Sarah Shires, PhD
Researcher and Technical Writer
Dr. Sarah Shires joined Edge Pharma in April 2020 as a researcher and technical writer. Shires earned her PhD in biomedical sciences from the University of California at San Diego. Shires became passionate about research during her undergraduate years, when she studied integrative physiology and Spanish at the University of Iowa.
As an undergraduate research assistant, Shires processed human blood samples and extracted DNA for a genome-wide methylation study. Her research resulted in authorship of an article focusing on DNA-methylation patterns in patients with alcoholism.
In graduate school, Shires managed a multifaceted biology project, designing experiments and generating data for several published studies. Through her research, Shires discovered an entirely new role for a protein whose dysfunction has been tied to both Parkinson’s Disease and cardiovascular disease. This research earned her several awards, including a Predoctoral fellowship grant in Cellular and Molecular Pharmacology.
At Edge, Shires works within quality control to conduct in-depth investigations of environmental monitoring excursions and deviations to ensure compliance for all Edge Pharma products.
Shires SE, Quiles JM, Najor RH, Leon LJ, Cortez MQ, Lampert MA, Mark A, and Gustafsson ÅB, Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia. Sci Rep. 2020 May 22;10(1):8499. doi: 10.1038/s41598-020-65438-7.
Shires SE, Gustafsson ÅB. Regulating Renewable Energy: Connecting AMPKα2 to PINK1/Parkin-Mediated Mitophagy in the Heart. Circ Res. 2018 Mar 2;122(5):649-651. doi: 10.1161/CIRCRESAHA.118.312655.
Hammerling BC, Shires SE, Leon LJ, Cortez MQ, Gustafsson ÅB. Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin. Small GTPases. 2017 Jul 11:1-8. doi: 10.1080/21541248.2017.1342749.
Shires SE, Kitsis RN, and Gustafsson ÅB. Beyond Mitophagy: The Diversity and Complexity of Parkin Function. Circulation Research. 2017 Apr 14;120(8):1234-1236. doi: 10.1161/CIRCRESAHA.116.310179.