Edge Pharma offers diltiazem 2% cream without requiring prescriptions for individual patients. As a FDA registered and inspected Outsourcing Facility, Edge is held to a high standard of quality in terms potency and consistency.
Diltiazem HCI Topical Cream (PF)
- Concentration - 2%
- Multiple dose 30 g container
- Storage: Room temperature and protect from light
1) Knight, J. S., Birks, M. and Farouk, R., “Topical Diltiazem Ointment in the Treatment of Chronic Anal Fissure.” Br J Surg, 88 (2001): 553–556.
"Fifty-one patients (75 per cent) experienced healing of the fissure after 2–3 months of treatment with topical diltiazem. Seventeen patients who did not heal were treated for a further 8 weeks with topical diltiazem. Eight of these patients subsequently healed with diltiazem. Fifty-nine of 67 patients who completed follow-up therefore healed on diltiazem ointment."
"Topical 2 per cent diltiazem ointment used as an agent for chemical sphincterotomy for chronic anal fissure offers significant healing rates but does not have a significant side-effect profile, which may aid compliance to treatment."
2) Shah, Monil et al. “Quality of Compounded Topical 2% Diltiazem Hydrochloride Formulations for Anal Fissure.” World Journal of Gastroenterology : WJG 19.34 (2013): 5645–5650.
"The use of topical 2% diltiazem hydrochloride for treating anal fissures is supported by multiple clinical trials and is recommended in published medical society practice parameters."
"This is the first study to show that when patients are prescribed topical 2% diltiazem cream for treatment of anal fissure, they receive compounded formulations from retail pharmacies that are misbranded in respect to potency approximately 50% of the time and that lack content uniformity approximately 40% of the time."
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