Intratympanic Dexamethasone Injection

 

Edge Pharma offers 24 mg/mL Dexamethasone for intratympanic Injection supplied in a 1 mL syringe.


Concentration = 24 mg/mL
Syringe Volume = 0.8 mL in a 1 mL syringe
Refrigerated storage
90 day BUD 

See Also:
Dexamethasone Iontophoresis Solution 

 

Sudden Sensorineural Hearing Loss

Sudden sensorineural hearing loss (SSHL), also known as acute unilateral deafness, is an emergency in otology. There is a sharp onset, generally over three days. “The natural background of SSHL is still unknown; spontaneous recovery happens in almost 30 percent of cases and it will recover mostly during the first two weeks after its onset.”(1) 

A variety of disorders can cause SSHL, however only about 10 percent of patients with SSHL have an identifiable cause. Some causes may include: 

  • Infections
  • Head Trauma
  • Autoimmune Disease
  • Exposure to certain drugs that treat cancer or severe infections
  • Blood circulation problems
  • Neurological disorders, such as Multiple Sclerosis
  • Disorders of the inner ear, such as Meniere’s Disease (2)  

Clinically, while SSHL has the possibility of spontaneous recovery, “all reports describing treatments indicate that early initiation of treatment will undoubtedly lead to improved prognoses.”(1) 

Systemic steroids are often used and known to improve hearing levels in patients with SSHL. “Higher steroid concentrations could be achieved in the inner ear and systemic side effects could be avoided by using intratympanic injection.”(3) 

A study published in the International Journal of Otorhinolaryngology and Head and Neck Surgery assessed the effect of intratympanic dexamethasone in patients with sudden sensorineural hearing loss. Hearing improvement was seen in 68 percent of patients who underwent this procedure. The study concluded, “Intratympanic dexamethasone significantly improves the prognosis of idiopathic sensorineural hearing loss and is a safe, inexpensive and effective treatment.” (4)  

A study published in The Journal of Laryngology and Otology also showed that prompt treatment with intratympanic steroid therapy improved patient outcomes. “Patients who received intratympanic steroid therapy within seven days of disease onset achieved a significantly better response rate (76.1 percent) compared with the delayed treatment group (50 percent). The total response rate, after four steroid injections, was 68.9 percent. Patients with low and mid-frequency hearing loss were more responsive to steroid treatment.”(5)


(1) Berjis, N., Soheilpour, S., Musavi, A., Hashemi, S., Journal of Advanced Biological Research, online article, Intratympanic Dexamethasone Injection vs. Methylprednisolone for theTreatment of Refractory Sudden Sensorineural Hearing Loss https://www.ncbi.nlm.nih.gov/ 

(2) National Institute on Deafness and Other Communications Disorders, U.S. Department of Health and Human Services, online article, Sudden Deafness https://www.nidcd.nih.gov/

(3) Yoshida, Tadao, Teranishi, Masaaki, Iwata, Tomoyuki, Otake, Hironao, Nakashima, Tsutomu, Journal of Audiology Research, online article, Intratympatic Injection of Dexamethasone for Treatment of Tinnitus in Patients with Sudden Sensorineural Hearing Loss https://www.ncbi.nlm.nih.gov/

(4) Swamy, K. MD, Ganiger, A. International Journal of Otorhinolaryngology and Head and Neck Surgery, online article, Effect of Intratympanic Dexamethasone Injection in Sudden Idiopathic Sensorineural Hearing Loss https://www.ijorl.com/

(5) Tasi, Y.J., Liang, J.G., Wu, W.B., Ding, Y.F., The Journal of Laryngology and Otology, online article, Intratympanic Injection with Dexamethasone for Sudden Sensorineural Hearing Losshttps://www.ncbi.nlm.nih.gov/

 

References

 

"I have autoimmune hearing loss that requires intratympanic injections of 24 mg/mL dexamethasone. As a dermatologist that utilizes a compounding pharmacy, I was familiar with the process to explore options when the one I was using could not provide this higher strength. Most compounding pharmacies have limited what they will supply to physicians and typically only provide a much lower dose. I really appreciate that EDGE Pharmacy Services continues to provide the higher strength dose required to keep my hearing loss at bay. The lower dose would have required either a higher oral dose, which is not desirable, or more frequent injections. I cannot thank them enough for providing this service. As a physician I truly appreciate EDGE for providing outstanding service for a difficult to fill need."

Suzanne L. Kilmer, MD
Director, Laser & Skin Surgery Center of Northern California
Clinical Professor, Dept of Dermatology, UC Davis

 

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