Anesthetic Nasal Solutions


nasal solutions outsourcing pharmacy


Edge Pharma is proud to be producing anesthetic combination nasal solutions for ENT practices and other qualified practitioners.  Ever since the passing of the Drug Quality & Security Act in 2013, it has become increasingly more difficult for physicians to find a suitable supplier of combination nasal solutions which are available for purchase in bulk.  Local and State-licensed compounding pharmacies are no longer able to dispense compounded medications without individual patient scripts for each order.  As an FDA-Registered 503B outsourcing facility, Edge Pharma is able to dispense bottles of anesthetic nasal solutions in bulk and without patient names for office-use.


Nasal Solution Lido Oxy

The following anesthetic nasal solution is available from Edge in 240mL bottles for intranasal use. Sold in 480mL units (2 bottles).

Storage: room temperature and protect from light

  • Lidocaine 4%/ Oxymetazoline 0.05%


There is no longer any reason for your practice to go without combination nasal solutions or for you to be compounding them in-office.  Let Edge Pharma provide a cost-effective solution developed and produced to CGMP standards in an FDA-Registered facility. 


Literature Review


Local Anesthetic and Nasal Endoscopy

Otolaryngologists perform a nasal endoscopy in order to examine nasal and sinus passages.(1) Healthcare providers may require an endoscopy because of several health issues, including:

  • Nasal congestion
  • Nasal blockage
  • Nasal and sinus infection
  • Nasal tumors
  • Nosebleeds
  • Loss of ability to smell
  • Cerebrospinal fluid leak(1)

“Rhinosinusitis is one of the most common reasons for nasal endoscopy.”(1) During the endoscopy, the healthcare provider can look for swelling and polyps, and also take samples from the affected area.(1)

“As a preparation for nasal endoscopy, a local anesthetic and/or decongestant are usually applied to nostrils in order to alleviate the nasal pain, to widen the field of view, and to shorten the duration of the examination.”(2)

A 2016 study, geared to identify the optimal pharmacological method of preparing patients for nasal endoscopy, tested four types of medications. Medication was administered through spray application in the nostrils. Study participants received either: placebo (normal saline), normal saline plus oxymetazoline, normal saline plus lidocaine, or lidocaine plus oxymetazoline. Rigid nasal endoscopy was performed 10 minutes after the spray application.(2) “The lowest pain score related to endoscopy was obtained for lidocaine-oxymetazoline,” the study reported. Additionally, the lidocaine-oxymetazoline combination enabled a “significantly shorter” duration of the endoscopy.(2) 

(1) Johns Hopkins Medicine, Nasal Endoscopy
(2) Sahin, M. MD, et al, Clinical and Experimental Otorhinolaryngology, Premedication Methods in Nasal Endoscopy: A Prospective, Randomized, Double-Blind Study


Nasal Polyps

Nasal polyps, which affect 2-5% of the population, develop when a person’s nasal passages are inflamed over a long period of time. Polyps can be large enough to block nasal passages, leading to breathing problems and loss of the sense of smell.(1)

According to a leading medical center, additional symptoms of chronic rhinosinusitis and nasal polyps include:

  • A runny nose
  • Persistent stuffiness
  • Postnasal drip
  • Decreased or absent sense of smell
  • Facial pain or headache
  • Pain in your upper teeth
  • A sense of pressure over your forehead and face
  • Snoring
  • Frequent nosebleeds(2)

For small nasal polyps, patients may be prescribed a corticosteroid nasal spray to shrink the polyps. Larger polyps that do not respond to this therapy generally require surgery.(3) In-office rhinologic procedures are increasingly common. The procedure to remove nasal polyps, endoscopy nasal polypectomy, is often done under local anesthesia in selected patients, providing immediate relief.(4)

A study examined the effectiveness of in-office nasal polypectomy on 44 patients. “Preparation of the nose was done using surgical patties soaked in a solution of oxymetazoline and lidocaine for at least 5 minutes.”(4) Patient tolerance was measured using the Visual Analog Score (VAS), with 0 meaning absence of pain and 10, intense pain. In this study, the mean score was 2.76.(4) Most of the patients had complete removal of the nasal polyps with six having a partial polypectomy.(4)

Lidocaine 4%/oxymetazoline 0.05% is also often used for nasal endoscopy, a medical procedure physicians use to examine the nasal and sinus passages. A study compared four combinations of medicines in nasal sprays, to identify the optimal combination for the procedure, for both pain control and length of procedure time. The lowest pain score was obtained for the combination lidocaine/oxymetazoline, and the procedure time was shorter than with other medicines. (5)

(1) American Academy of Allergy, Asthma & Immunology, Nasal Polyps Definition,
(2) Mayo Clinic, Nasal Polyps,
(3) Harvard Health Publishing, Nasal Polyps,
(4) Viera-Artiles, J. M.D., Corriolos-Noval, P. M.D., U.S. National Library of Medicine, In-office Endoscopic Nasal Polypectomy: Prospective Analysis of Patient Tolerability and Efficacy,
(5) Sahin, M. M.D., Kokoglu, K. M.D., et. al, Clinical and Experimental Otorhinolaryngology, Premedication Methods in Nasal Endoscopy: A Prospective, Randomized, Double-Blind Study,


Register To Order Online 

We are currently licensed to sell to all US states except Alabama and Virginia. Please fill the form below to create an account. Medical, DEA, or hospital pharmacy licenses will be required to order nasal solutions online.

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