Dexamethasone Iontophoresis Solution


Dexamethasone sodium phosphate topical solution

Edge Pharma is proud to offer dexamethasone iontophoresis solution for physical therapy practices. Ever since the passing of the Drug Quality & Security Act in 2013, it has become increasingly more difficult to find a suitable supplier of iontophoresis solutions available for purchase in bulk. Local and State-licensed compounding pharmacies are no longer able to dispense compounded medications without individual patient scripts for each order. As an FDA-Registered 503B Outsourcing facility, Edge Pharma is able to dispense bottles of iontophoresis solution in bulk for office use, without requiring patient names.

Dexamethasone iontophoresis solution from Edge is packaged in multi-dose bottles that can be kept in your office for use on multiple patients. This product requires that the ordering individual or facility have the ability to order prescription medications. If you are a hospital-affiliated clinic, your hospital pharmacy can order this product.


Dexamethasone Sodium Phosphate


Equivalent to dexamethasone 4mg/mL. Topical solution for negative polarity iontophoresis. 120mL multiple dose container for topical use.

Storage: refrigerate and protect from light

  • Dexamethasone 0.4% Iontophoresis Solution
  • Min order requirement 2 bottles
  • Volume discounts available


See Also:
Dexamethasone Intratympanic injection


Literature Review


Iontophoresis and Dexamethasone

Iontophoresis is an electrical stimulation that is a therapeutic modality often used in physical therapy. While different medications are used in iontophoresis, depending on the condition being treated, dexamethasone is commonly used.(1)

A study that included 82 patients with epicondylitis (tennis elbow) compared the injection of dexamethasone with the delivery of dexamethasone via iontophoresis on patient outcomes. Outcome criteria included pain, grip strength, function, and return-to-work status. The results stated: “The iontophoresis patients had statistically significant improvement in grip strength at the conclusion of hand therapy compared with baseline. They were also more likely to get back to work without restriction. This study suggests that this iontophoresis technique for delivery of corticosteroid may be considered a treatment option for patients with lateral epicondylitis.”(2)

A study conducted at a pediatric rheumatology center assessed the safety and efficacy of dexamethasone iontophoresis for the treatment of temporomandibular joint (TMJ) involvement in children with juvenile idiopathic arthritis. Children and adolescents with juvenile idiopathic arthritis are prone to TMJ arthritis. “Besides pain, swelling, and limitation in the range of motion, TMJ arthritis can present with headaches, neck pain, and pain with mastication. If untreated and persistent, TMJ arthritis can result in micro-retrognathia, facial asymmetry, and therefore, decreased quality of life.”(3)

The study results showed that 69 percent of patients who received dexamethasone iontophoresis experienced statistically significant improvement. Resolution of pain occurred in 73 percent of the patients. The study concluded, “In this pilot study, DIP (dexamethasone iontophoresis) appeared to be an effective and safe initial treatment of TMJ involvement in juvenile idiopathic arthritis, especially among patients with decreased TMJ measurements.”(3)

(1) Sears, B. PT, verywell health, Iontophoresis Medications Used in Physical Therapy,
(2) Stefanou, A., et al, Journal of Hand Surgery, A Randomized Study Comparing Corticosteroid Injection to Corticosteroid Iontophoresis for Lateral Epicondylitis,
(3) Mina, R. MD, et al, Arthritis Care and Research, Effectiveness of Dexamethasone Iontophoresis for Temporomandibular Joint Involvement in Juvenile Idiopathic Arthritis,



"Dexamethasone is the most commonly used medication with iontophoresis to treat a variety of connective tissue disorders." (


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