Vitamin K (Phytonadione) Oral Solution
Edge Pharma produces vitamin K (phytonadione) oral solution for use in hospitals. Phytonadione is a fat-soluble vitamin synthesized by plants. Edge olive oil based oral vitamin K is a ready-to-administer solution with extended Beyond Use Dating (BUD). This allows hospital pharmacies to have an on-hand and cost effective option.
Vitamin K (Phytonadione) Oil-Based Oral Solution
Single dose syringe for oral use. Room temperature storage.
- Concentration: 5 mg/ml
- Volume: 1 mL per syringe
- Container: 3 mL Oral Syringe
More than 2 million people in the United States take blood thinning drugs each day for cardiovascular, pulmonary, and hypercoagulable disorders.(1) According to a major medical center, blood thinners, such as Warfarin (Coumadin®, Jantoven®), may be prescribed for a number of conditions, including:
• A blood clot in or near the heart that could trigger stroke, heart attack, or organ damage
• A blood clot in the lungs (pulmonary embolism)
• A blood clot elsewhere in the body (venous thrombosis)
• A high risk of blood clots forming in the heart, which can be a complication of some heart rhythm abnormalities (arrhythmias)
• A mechanical artificial heart valve that is prone to forming blood clots (2)
Warfarin is a Vitamin K antagonist. The goal of therapy with Warfarin is to maintain the target international normalized ratio (INR) with the lowest effective dose. “The safety and efficacy of Warfarin therapy are dependent on maintaining the INR within the target range for the indication.” A major risk factor of Warfarin is bleeding, which correlates with INR values.(3)
Each year, up to 6.5 percent of patients on anticoagulant therapy experience a major bleeding event, and approximately 1 percent will develop a fatal bleed. There are several methods to reverse the anticoagulant effect of Warfarin, including, but not limited to: omission of a dose of Warfarin, administration of an oral or intravenous dose of Vitamin K, and the use of fresh frozen plasma.(4)
“In over anti-coagulated patients, Vitamin K aims at rapid lowering of the international normalized ratio (INR) into a safe range to reduce the risk of major bleeding and therefore improving patient outcome without exposing the patient to the risk of thromboembolism due to overcorrection, resistance to anticoagulation with antivitamin K (AVK), or an allergic reaction to the medication.”(5)
(1) Ahmed, M., World of Gastrointestinal Endoscopy, Blood Thinners and Gastrointestinal Endoscopy, https://www.ncbi.nlm.nih.gov/
(2) Mayo Clinic, online article, Warfarin Side Effects: Watch for Interactions, https://www.mayoclinic.org/
(3) Kuruvilla, M. PharmD, Gurk-Turner, C. RPH, Journal of the Department of Pharmacy Services, Baylor University, A Review of Warfarin Dosing and Monitoring, https://www.ncbi.nlm.nih.gov/
(4) Zareh, M.,Davis, A., Henderson, S. MD, West Journal of Emergency Medicine, Reversal of Warfarin-Induced Hemorrhage in the Emergency Department, https://www.ncbi.nlm.nih.gov/
(5) Hanslik, T., Prinseau, J. The Use of Vitamin K in Patients on Anticoagulant Therapy: A Practical Guide, American Journal of Cardiovascular Drugs, https://doi.org/
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