Compounded Ophthalmic Medications

 

ophthalmology compounded medications

 

Edge Pharma is a USP 795, 797, 800 and CGMP compliant FDA-Registered 503B Outsourcing Facility that specializes in a wide array of sterile and non-sterile compounded medications. Edge provides high quality medications with longer Beyond Use Dating and batch testing for every lot manufactured. We pride ourselves on working with customers to solve their compounding needs. In addition, as an Outsourcing Facility, Edge is able to dispense these products to qualified practitioners and facilities without patient names.

Sterile compounded medications are a key component to every ophthalmic surgeon's regular protocols. Outsourcing the compounding of these vital medications with Edge offers several distinct advantages compared to supplying vials.

  • USP 797 Compliance - You no longer have to be concerned that any provider is compounding in an unclassified space.
  • Waste Reduction - Large vials and bottles create waste due to restrictive compounding guidelines that often require them to be used as a unit dose.
  • Cost Savings - Choosing to outsource with Edge can reduce your overall cost for acquiring many ophthalmic medications.

 

Available Ophthalmic Medications

 

Bevacizumab Injections: It is a new biosimilar to Avastin® that is widely used off-label in ophthalmology. Compliance and convenience are now possible with Edge Pharma's unit dose MVASI™ Bevacizumab-awwb syringes.

 

Ophthalmic Blocks: Pre-mixed ready-to-administer retrobulbar and peribulbar ophthalmic blocks dispensed in unit dose syringes.

Ophthalmic Combination Dilating Drops: Pre-operative mydriatics comprised of up to six active pharmaceutical ingredients. The drops are offered in both multi-dose and individual dose packaging.

 

Dilating Injections: Intraocular compounds dispensed in unit dose syringes used during surgery to enhance dilation.

 

Antimicrobial Injections: A variety of post-operative antibiotic injections offered in unit dose syringes

 

Ophthalmic Dyes: Injections packaged in a pre-filled unit dose syringes. Dyes are used in ophthalmology, both as diagnostic and therapeutic aid.

 

Endophthalmitis Injections

 

Other Ophthalmic Medications

 

Our online system makes ordering quick and easy. Just go to a product page and submit a simple form to setup an account with Edge.

 

Literature Review


Almost 30 million Americans are affected by cataracts, and with the aging of the population, that number is projected to rise dramatically within the next few decades. The National Institutes of Health reports that more than half of all Americans will either have cataracts or will have had cataract surgery by the time they reach the age of 80. Most cataracts are caused by normal changes as a result of aging.(1)

The greatest increase in cataract surgery is between people aged 70-80, largely because aging baby boomers are staying in the workforce longer, desiring to be more active, placing more demands on their vision.(2) Cataract surgery is the most frequently performed surgery throughout the world, with an estimated 10 million surgeries completed each year. Most patients have improved vision after surgery with uncomplicated post-operative courses.(3)

Endophthalmitis, an infection of the fluids or tissues inside the eye, is a medical emergency that requires immediate medical treatment. It can cause blindness if not treated promptly.(4) The infection is an uncommon complication of cataract surgery. It is reported to occur at rates between 0.03 percent and 0.2 percent of all cataract surgeries.(3)

While all intraocular procedures have some risk of endophthalmitis, it is most commonly reported following cataract surgery and intravitreal injections, because of the large numbers of these procedures carried out globally. Prompt treatment is vital when endophthalmitis is diagnosed. “In order to achieve a rapid response, it is important to have an accessible protocol and an endophthalmitis kit at hand for all eye surgeons who see postoperative patients.”(5)

Prevention of endophthalmitis begins well before surgery, with practitioners assuring that: the patient has been compliant with preoperative instructions, instruments are properly sterilized, and the preoperative surgical scrub has been completed. At the conclusion of surgery, the intracameral injection of the antibiotic cefuroxime has been shown to reduce the incidence of endophthalmitis.(6) Likewise, a clinical trial conducted in 2016 studying the effectiveness of an injection of moxifloxacin at the conclusion of surgery also showed a reduction in the incidence of endophthalmitis.(7)

Symptoms of endophthalmitis include eye pain, red eyes, discharge from the eyes, swollen eyelids and decreased vision.(8) Once diagnosed, the standard treatment for endophthalmitis is intravitreal antibiotics. Vancomycin is indicated for gram-positive coverage and ceftazidime or an aminoglycoside is indicated for gram negative coverage, according to an article in the Journal of Clinical Microbiology.(9) Between 70 and 80 percent of post-operative endophthalmitis is caused by coagulase-negative staphylococci, and when treated immediately, the prognosis for vision is good.(10)

(1) National Eye Institute, online article, Cataracts https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/cataracts

(2) Zagaria, M. U.S. Pharmacist Magazine, online article, Postoperative Endophthalmitis After Cataract Surgery https://www.uspharmacist.com/article/postoperative-endophthalmitis-after-cataract-surgery

(3) George, N. and Stewart, M., Ophthalmology and Therapy, online article, The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258587/

(4) Mukamal, R., American Academy of Ophthalmology, online article, What is Endophthalmitis? https://www.aao.org/eye-health/diseases/what-is-endophthalmitis

(5) Niyadurupola, N. and Astbury, N., Community Eye Health Journal, U.S. National Library of Medicine, National Institutes of Health, online article, Postoperative Endophthalmitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675262/

(6) Niyadurupola, N. and Astbury, N., Community Eye Health Journal, U.S. National Library of Medicine, National Institutes of Health, online article, Endophthalmitis: Controlling Infection Before and After Cataract Surgery https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377381/

(7) Singer, J., online article, American Academy of Ophthalmology Journal, Intracameral Moxifloxacin After Routine Cataract Surgery Appears Safe https://www.aao.org/editors-choice/intracameral-moxifloxacin-after-routine-cataract-s

(8) Mukamal, R., online article, American Academy of Ophthalmology, What is Endophthalmitis? https://www.aao.org/eye-health/diseases/what-is-endophthalmitis

(9) Chen, K., Chen, T., et. al., online article, Journal of Clinical Microbiology, Endophthalmitis: Antibacterial Activity of Precipitates of Vancomycin and Ceftazidime https://www.bing.com/search?q=vanomycin%20and%20ceftazidime%20and%20endophthalmitis&FORM=O1HV

(10) Panda, H. MD, Dee McGee Eye Institute, University of Oklahoma College of Medicine, online article, Medscape, Postoperative Endophthalmitis https://emedicine.medscape.com/article/1201260-clinical


 

(1) National Eye Institute, online article, Cataracts https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/cataracts(2) Zagaria, M. U.S. Pharmacist Magazine, online article, Postoperative Endophthalmitis After Cataract Surgery https://www.uspharmacist.com/

(3) George, N. and Stewart, M., Ophthalmology and Therapy, online article, The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence? https://www.ncbi.nlm.nih.gov/

(4) Mukamal, R., American Academy of Ophthalmology, online article, What is Endophthalmitis? https://www.aao.org/

(5) Niyadurupola, N. and Astbury, N., Community Eye Health Journal, U.S. National Library of Medicine, National Institutes of Health, online article, Postoperative Endophthalmitis https://www.ncbi.nlm.nih.gov/

(6) Niyadurupola, N. and Astbury, N., Community Eye Health Journal, U.S. National Library of Medicine, National Institutes of Health, online article, Endophthalmitis: Controlling Infection Before and After Cataract Surgery https://www.ncbi.nlm.nih.gov/

(7) Singer, J., online article, American Academy of Ophthalmology Journal, Intracameral Moxifloxacin After Routine Cataract Surgery Appears Safe https://www.aao.org/editors-choice/intracameral-moxifloxacin-after-routine-cataract-s

(8) Mukamal, R., online article, American Academy of Ophthalmology, What is Endophthalmitis? https://www.aao.org/

(9) Chen, K., Chen, T., et. al., online article, Journal of Clinical Microbiology, Endophthalmitis: Antibacterial Activity of Precipitates of Vancomycin and Ceftazidime https://www.bing.com/search?q=vanomycin%20and%20ceftazidime%20and%20endophthalmitis&FORM=O1HV

10) Panda, H. MD, Dee McGee Eye Institute, University of Oklahoma College of Medicine, online article, Medscape, Postoperative Endophthalmitis https://emedicine.medscape.com/article/1201260-clinical