Cefuroxime Ophthalmic Injection PF
Edge Pharma offers cefuroxime antibiotic single-dose injections for use by hospitals and surgery centers.
Cefuroxime Prophylactic Antimicrobial Injection
Concentration = 10 mg/mL
Syringe Volume = 0.3 mL (Unit dose)
Cataract is the leading cause of blindness worldwide. While cataract surgery is generally considered safe, with the result of improved vision, complications can occur. “The most feared complication is postoperative endophthalmitis which is an infectious condition caused by micro‐organisms introduced to the interior of the eye during or after the surgical procedure.”(1)
Prevention of endophthalmitis begins well before surgery, with practitioners assuring that the patient has been compliant with preoperative instructions, instruments are properly sterilized, and the preoperative scrub has been completed.
A 2007 multinational landmark study on the prevention of endophthalmitis in 24 ophthalmology clinics examined the prophylactic effect of intracameral cefuroxime after cataract surgery to prevent endophthalmitis. The study was anticipated to include approximately 16,000 patients. After 13,698 study patient charts had been reviewed, the study was terminated. “Such a clear beneficial effect from the use of intracameral cefuroxime had been observed that it was agreed it would be unethical to continue the study and to wait for the completion of all follow-up procedures before reporting this important result.”(2) In the study, the incidence rate of endophthalmitis in patients who did not receive cefuroxime prophylaxis was almost five times the rate of patients receiving cefuroxime.(2)
A study conducted at a large health system between 2007-2011 also examined the effectiveness of intracameral antibiotic injections. For this study, three time periods were identified based on increasing use of intracameral injections after cataract surgery. In 2007, patients received postoperative antibiotic drops. In 2008 and 2009, patients received intracameral antibiotics (84% received cefuroxime, 15% moxifloxacin, 1% vancomycin) in addition to post-operative drops. During 2010 and 2011, all patients received intracameral injections; some also received topical antibiotic drops at the discretion of the surgeon.(3)
The researchers analyzed more than 16,000 charts of cataract surgery patients and “found the rate of endophthalmitis dropped 22-fold when intracameral antibiotics were used.”(4)
(1) Kessel, L., Flesner, P., et. al, ACTA Ophthalmologica, Ophthalmology, Antibiotic Prevention of Post Cataract Endophthalmitis: A Systematic Review and Meta‐analysis, https://onlinelibrary.wiley.com/
(2) Barry, P., Seal, D. M.D. et. al., Journal of Cataract and Refractive Surgery, ESCRS Study of Postoperative Endophthalmitis After Cataract Surgery, https://pubmed.ncbi.nlm.nih.gov/
(3) Journal of Cataract and Refractive Surgery, Decreased Postoperative Endophthalmitis Rate after Institution of Intracameral Antibiotics in a Northern California Eye Department https://pubmed.ncbi.nlm.nih.gov/
(4) Roach, L. EyeNet Magazine, American Academy of Ophthalmology, Intracameral Antibiotics: What the Evidence Shows, https://www.aao.org/eyenet/
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