Epi-Shugarcaine Injection


Edge Pharma offers preservative-free epi-shugarcaine injection in a pre-filled unit dose syringe.


Epi-Shugarcaine Injection

Concentration = Epinephrine 0.025% / Lidocaine 0.75%
Syringe Volume = 0.8 mL


Literature Review


Shugarcaine -- was the first anesthesia developed for use inside the eye. Invented in 1997 by Dr. Joel Shugar, the buffered lidocaine solution “is widely used in cataract surgery,” according to the medical journal Ophthalmology Management. Shugar was a pioneering ophthalmologist who trained as an electrical engineer before earning his MD and then pursuing ophthalmology as a resident at the University of Florida. [read more]




Myers, William G., and Joel K. Shugar. "Optimizing the Intracameral Dilation Regimen for Cataract Surgery: Prospective Randomized Comparison of 2 Solutions." Journal of Cataract & Refractive Surgery 35.2 (2009): 273-276.

The authors compared the use of epi-Shugarcaine (epinephrine 0.025% / lidocaine 0.75%) and Lundberg and Behndig's intracameral dilation solution (cyclopentolate 0.1% / phenylephrine 1.5% / lidocaine 1%) for cataract surgery intracameral dilation. Although the lidocaine concentration was different between the two case, their results provide data comparing the use of epinephrine versus a combination of cyclopentolate and phenylephrine for dilation.

 "Eighty-four eyes of 42 patients were enrolled in the study. At each time point after instillation, the pupil was statistically significantly larger with epi-S solution than with LB solution."

 "When combined with 1 drop of tropicamide 1% preoperatively, both formulations provided safe and effective intracameral dilation for cataract surgery; however, the epi-S solution was the more efficacious at each step of the procedure."


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