Ophthalmic Moxifloxacin


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Edge Pharma offers moxifloxacin ophthalmic antimicrobial injection for use by hospitals and surgery centers. It is offered in unit dose syringes.


Moxifloxacin Ophthalmic Injection

  • Balanced Salt Solution
  • Concentration = 1.0 mg/mL
  • Syringe Volume = 0.8 mL
  • Note: Formulation does not contain Xanthan Gum.



1) Haripriya, Aravind, et al. "Efficacy of Intracameral Moxifloxacin Endophthalmitis Prophylaxis at Aravind Eye Hospital." Ophthalmology 123.2 (2016): 302-308.

"Routine IC moxifloxacin prophylaxis achieved a highly significant, 4-fold reduction in postoperative endophthalmitis in patients undergoing M-SICS. Compared with previous studies, having such a high volume of patients undergoing surgery during a relatively short 14-month time period strengthens the conclusion. This study provides further evidence that moxifloxacin is an effective IC prophylactic antibiotic and suggests that IC antibiotics should be considered for M-SICS and phacoemulsification."

2) Haripriya, Aravind, David F. Chang, and Ravilla D. Ravindran. "Endophthalmitis Reduction with Intracameral Moxifloxacin Prophylaxis: Analysis of 600 000 Surgeries." Ophthalmology (2017).

"Overall, 302 815 eyes did not receive IC moxifloxacin and 314 638 eyes did, and there was a significant decline in the endophthalmitis rate, from 0.07% (214/302 815) to 0.02% (64/314 638) (P < 0.001), with moxifloxacin."

"There was also a statistical benefit for eyes complicated by PCR, and IC antibiotic prophylaxis should be strongly considered for this high-risk population."


Literature Review


Cataract surgery and Moxifloxacin

Almost 30 million Americans are affected by cataracts, and with the aging of the population, that number is projected to rise dramatically within the next few decades.(1)

The greatest increase in cataract surgery is between people aged 70-80, largely because aging baby boomers are staying in the workforce longer, desiring to be more active, placing more demands on their vision. (2) Cataract surgery is the most frequently performed surgery throughout the world, with an estimated 10 million surgeries completed each year. Most patients have improved vision after surgery with uncomplicated post-operative courses.(3)

Endophthalmitis, an infection of the fluids or tissues inside the eye, is a medical emergency that requires immediate medical treatment. It can cause blindness if not treated promptly.(4) The infection is an uncommon complication of cataract surgery. It is reported to occur at rates between 0.03 percent and 0.2 percent of all cataract surgeries.(3)

While all intraocular procedures have some risk of endophthalmitis, it is most commonly reported following cataract surgery and intravitreal injections, because of the large numbers of these procedures carried out globally.(5)

Prevention of endophthalmitis begins well before surgery, with practitioners assuring that the patients has been compliant with preoperative instructions, instruments are properly sterilized, and the preoperative surgical scrub has been completed. At the conclusion of the surgery, the intracameral injection of an antibiotic, such as moxifloxacin, is widely used and has been shown to reduce the incidence of endophthalmitis.(6)

A study of 3640 patients compared rates of endophthalmitis between 1818 patients who received an intracameral injection of moxifloxacin after surgery with 1822 who did not receive the injection. The rate was endophthalmitis was 0.05% in the moxifloxacin group and 0.38% in the control group. The study concluded that the intracameral injection of moxifloxacin can be safely applied as the last step of phacoemulsification. “It was found to be effective in reducing the risk for endophthalmitis.”(6)

(1) National Eye Institute, online article, Cataracts https://www.nei.nih.gov/
(2) Zagaria, Mary Ann E., U.S. Pharmacist Magazine, online article, Postoperative Endophthalmitis After Cataract Surgeryhttps://www.uspharmacist.com/
(3) George, Nicholas K, and Stewart, Michael W., Ophthalmology and Therapy, online article, The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence? https://www.ncbi.nlm.nih.gov/
(4) Mukamal, Reena, American Academy of Ophthalmology, online article, What is Endophthalmitis?https://www.aao.org/
(5) Niyadurupola, Nuwan, and Astbury, Nick, Community Eye Health Journal, U.S. National Library of Medicine, National Institutes of Health, online article, Postoperative Endophthalmitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675262/
(6) Melega, M. M.D., Alves, M. PhD., et.al. Journal of Cataract and Refractive Surgery, Safety and Efficacy of Intracameral Moxifloxacin for Prevention of Post-Cataract Endophthalmitis: Randomized Clinical Trial, https://journals.lww.com/jcrs/Abstract/2019/03000/Safety_and_efficacy_of_intracameral_moxifloxacin.14.aspx


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