Profound Gel

 

profound gels

  

Profound Gel is a topical oral anesthetic gel comprised of 4 active ingredients including lidocaine, prilocaine, tetracaine,  and phenylephrine. Edge Pharma offers Profound Gel to dentists and other qualified practitioners in a 30 gram jar without requiring patient names. The raspberry marshmallow flavor is popular due to its effectiveness in masking the inherent bitterness of oral anesthetics. Mint is also available.

Profound Gel can be ordered in quantities as low as a two jars. Quantity discounts are available. We also offer discounts for monthly subscriptions. 

Storage: room temperature

 

Profound Gel Ingredients 

  • Lidocaine 10%
  • Prilocaine 10%
  • Tetracaine 4%

 

Profound-PE Gel Ingredients 

  • Lidocaine 10%
  • Prilocaine 10%
  • Tetracaine 4%
  • Phenylephrine 2%

 

Lidocaine - Lidocaine is a very short acting local anesthetic originally discovered in the 1940s. It is comprised of synthetic aminoethylamide, and is commonly used as a numbing agent, working by inhibiting sodium channel ion flux, thus blocking nerve impulses.

Prilocaine - Prilocaine is a short acting topical local anesthetic, chemically designated as an amide, which provides dermal analgesia. Onset time after administration is slightly longer than lidocaine, but duration of action is also longer.

Tetracaine - Tetracaine is a longer acting local anesthetic that works by affecting calcium channel function. Tetracaine may take up to 15 minutes before onset of action, but the duration is also longer than either lidocaine or prilocaine (typically 2-3 hours).

Phenylephrine - Phenylephrine is a phenethylamine primarily used as a decongestant, vasopressor, and vascular constrictor.

 

Testimonials  

“I use Profound Gel every day, and truthfully I wouldn't even want to think about what my practice would be like without having an effective topical anesthetic.  Besides using it as a pre-injection gel for 3 minutes on dry mucosa, we also use it for root planing and most of our soft tissue laser procedures.  Sure beats hurting people!”

Dr. Marty Zase
Cosmetic Dentist and Lecturer on
"Cosmetic Pearls for the General Practitioner"

martyzase@aol.comwww.colchesterdentalgroup.com

 

Literature Review

  

TADs and Topical Anesthesia

Although Temporary Anchorage Devices (TADs) have been used by orthodontists for 35 years, their use has become commonplace in the last decade.(1) TADs enable orthodontists to achieve clinical solutions that were not possible with traditional anchorage modalities, such as headgear.(2) “Various types of complex malocclusions can now be successfully treated using TADs.”(2) TADs are used to treat a number of orthodontic issues, including corrections in anteroposterior, vertical, and transverse dimensions.(2)

Advantages cited for TADs include absolute anchorage, easy positioning and removing, low cost, and no requirement for patient cooperation.(3)

With the advent of TADs and their increasing popularity, orthodontists are facing the need to achieve adequate anesthesia in order to place the devices.(4) Different types of topical anesthetics are used before orthodontic procedures, such as a placement of TADs.(5) One choice is a formulation of 10% lidocaine, 10% prilocaine, and 4% tetracaine.(5) “The topical gel is applied for two minutes before performing a laser technique, miniscrew insertion, band seating, or any other mildly invasive procedure, and then thoroughly rinsed.”(5) 


(1) Harrell, R. DMD, Decisions in Dentistry: The Journal of Multidisciplinary Care, Clinical Uses for Temporary Anchorage Devices, https://decisionsindentistry.com/
(2) Park, J.H. DMD, Shine, K. DMD, Temporary Anchorage Devices in Clinical Orthodontics, An Overview of Clinical Applications for Temporary Anchorage Devices (TADs), https://onlinelibrary.wiley.com/
(3) Candido, C. DMD, Webmed Central, Open Access Biomedical Publishers, Use of Temporary Anchorage Devices in Orthodontics: A Review of the Literature, https://www.webmedcentral.com/
(4) Harris, L. DMD, et.al., Orthodontic Update, An Update on Local Anesthesia in Orthodontics, https://www.magonlinelibrary.com/
(5) Graham, J. DDS, Journal of Clinical Orthodontics, Profound, Needle-Free Anesthesia in Orthodontics, http://www.ameditech.com/ (PDF)

 

Managing Anxiety and Pain in the Dentist Chair

Some 22% of adults in the U.S. report being fearful of the dentist, according to the American Dental Association.(1) Fear of pain is often listed as the foremost concern, followed by fear of injections, of anesthetic side effects, and the general feeling of helplessness.(2)

An important way dentists work to manage pain is to combine topical and local anesthesia. “Topical anesthesia is a numbing gel that can help ease the insertion of a thin needle used to deliver local anesthesia.”(3) The topical anesthetics are recognized as useful in reducing pain, discomfort, and anxiety in a variety of dental procedures. Heightened anesthetic effects are achieved by combining several ingredients, according to a major dental publication.(4)

Compounded topical anesthetics, such as 10% lidocaine, 10% prilocaine, and 4% tetracaine, are gaining popularity in dental practices.(5) According to an article in an anesthesia journal, the benefits are two-fold: “Specifically, topical anesthetic helps to relieve anxiety and pain through both psychological and pharmacologic effects. Psychologically, subjects who are informed they are going to receive topical anesthetic may experience less anticipated pain and may experience decreased apprehension. Physiologically, reduction in pain is achieved by blocking nerve impulse conduction in the free nerve endings located within the superficial tissues through the temporary decrease of sodium ion permeability in the nerve cell membrane.”(5)


(1) Maestri, G. D.D.S., Dentistry Today, How to Address Dental Anxiety During the Pandemic, https://www.dentistrytoday.com/
(2) Web MD, Easing Dental Fear in Adults, https://www.webmd.com/
(3) Jiang, T. D.M.D., Harvard Health Publishing, Drills Needles, and Pain, Oh My! Coping with Dental Anxiety, https://www.health.harvard.edu/
(4) Lee, H. D.D.S., Journal of Dental Anesthesia, and Pain Medicine, Recent Advances in Topical Anesthesia, https://www.ncbi.nlm.nih.gov/
(5) Park, L. D.D.S., Tom, J. D.D.S., Anesthesia Progress, Comparing the Efficacy of a Compound Topical Anesthetic Versus Benzocaine: A Pilot Study, https://www.ncbi.nlm.nih.gov/

 

Register To Order Online 

We are currently licensed to sell to all US states except Alabama and Virginia. Our online system makes ordering quick and easy. Just submit the simple form below to setup an account with Edge. Medical, DEA, or hospital pharmacy licenses will be required to order profound gel.

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