Profound Gel


profound gels


Profound Gel is a topical oral anesthetic gel comprised of 4 active ingredients including lidocaine, prilocaine, tetracaine,  and phenylephrine. Edge Pharma offers Profound Gel to dentists and other qualified practitioners in a 30 gram jar without requiring patient names. The raspberry marshmallow flavor is popular due to its effectiveness in masking the inherent bitterness of oral anesthetics. Mint is also available.

Profound Gel can be ordered in quantities as low as a two jars. Quantity discounts are available. We also offer discounts for monthly subscriptions. 

Storage: room temperature


Profound Gel Ingredients 

  • Lidocaine 10%
  • Prilocaine 10%
  • Tetracaine 4%


Profound-PE Gel Ingredients 

  • Lidocaine 10%
  • Prilocaine 10%
  • Tetracaine 4%
  • Phenylephrine 2%


Lidocaine - Lidocaine is a very short acting local anesthetic originally discovered in the 1940s. It is comprised of synthetic aminoethylamide, and is commonly used as a numbing agent, working by inhibiting sodium channel ion flux, thus blocking nerve impulses.

Prilocaine - Prilocaine is a short acting topical local anesthetic, chemically designated as an amide, which provides dermal analgesia. Onset time after administration is slightly longer than lidocaine, but duration of action is also longer.

Tetracaine - Tetracaine is a longer acting local anesthetic that works by affecting calcium channel function. Tetracaine may take up to 15 minutes before onset of action, but the duration is also longer than either lidocaine or prilocaine (typically 2-3 hours).

Phenylephrine - Phenylephrine is a phenethylamine primarily used as a decongestant, vasopressor, and vascular constrictor.



“I use Profound Gel every day, and truthfully I wouldn't even want to think about what my practice would be like without having an effective topical anesthetic.  Besides using it as a pre-injection gel for 3 minutes on dry mucosa, we also use it for root planing and most of our soft tissue laser procedures.  Sure beats hurting people!”

Dr. Marty Zase
Cosmetic Dentist and Lecturer on
"Cosmetic Pearls for the General Practitioner"


Register To Order Online 

We are currently licensed to sell to all US states except Alabama and Virginia. Our online system makes ordering quick and easy. Just submit the simple form below to setup an account with Edge. Medical, DEA, or hospital pharmacy licenses will be required to order profound gel.


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