Buffered Lidocaine with Epinephrine 


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Edge Pharma offers Buffered 1% Lidocaine with 1:100,000 Epinephrine in 3 mL unit-dose syringes.


Buffered Lidocaine 1% with Epinephrine

Sterile buffered solution for injection (PF)
Concentration = 1% Lidocaine / 1:100,000 Epinephrine
Storage: refrigerated
Syringe Volume = 3 mL


buffered lidocaine sterile

See Also:
Buffered 1% Lidocaine


Literature Review


Buffered Lidocaine with Epi and Mohs Surgery

Mohs micrographic surgery is a technique used to treat skin cancer.(1) “During Mohs surgery, thin layers of cancer-containing skin are progressively removed and examined until only cancer-free tissue remains.”(1) According to the Skin Cancer Foundation, Mohs surgery is considered the most effective treatment for the two most common types of skin cancer, basal cell carcinoma and squamous cell carcinoma. In some instances, surgeons use Mohs on patients with melanoma. Before surgery, a Mohs surgeon injects a local anesthetic which numbs the area of the procedure.(2) “The most commonly employed medicines in Mohs surgery are lidocaine and epinephrine.”(3)

In a study published in a major medical journal, 200 patients underwent Mohs surgery, with local anesthetic of 1% or 2% lidocaine and epinephrine at a concentration of 1:100,000, administered preoperatively and intraoperatively. Of the total patients 2% experienced a reaction to epinephrine, which was characterized as a subjective sensation of tremulousness within five minutes of administration. No vital sign changes were reported.(4)

The study concluded: “Systemic reactions to epinephrine from local anesthetics are an infrequent adverse event in MMS cases. The data suggest that the absolute dose of local anesthetic with epinephrine does not correlate with the risk of developing an epinephrine reaction. Older age seems to have a protective effect.”(4)

(1) Mayo Clinic, Mohs Surgery, https://www.mayoclinic.org/
(2) Skin Cancer Foundation, Mohs Surgery, https://www.skincancer.org/
(3) Nouri, K. editor, Springer Science and Business Media, Mohs Micrographic Surgery, https://books.google.com/books
(4) McLawhorn, J., et. al., Dermatology, Incidence of Epinephrine Reactions with Local Anesthesia in Mohs Micrographic Surgery, https://pubmed.ncbi.nlm.nih.gov/


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