Methacholine Challenge Test Kit
The Edge Methacholine Challenge Test Kit comes as a pre-filled ready-to-administer set of 5 sterile solutions. Now with room temperature storage and extended beyond use dating.
- Prefilled, color coded, and barcoded unit dose syringes are simple, safe, and convenient to use.
- No compounding or dilutions are necessary in the Pharmacy or by a respiratory therapist because our kit comes ready-to-administer.
- No more mislabeled or unlabeled syringes.
Every batch of our Methacholine Challenge Kits undergoes rigorous testing to verify the contents of each syringe for sterility, potency, and endotoxin limits.
- Stability studies have allowed us to provide extended Beyond Use Dating (BUD) and room temperature storage, virtually eliminating wasted doses.
Methacholine Challenge Test Kit Concentrations (3 mL per Syringe)
- 16 mg/ml
- 4 mg/ml
- 1 mg/ml
- 0.25 mg/ml
- 0.062 mg/ml
Methacholine Challenge Test (MCT)
The diagnosis of asthma is based on a number of factors, including a patient’s overall health, a detailed medical history, a physical exam, symptoms, and test results.(1) Historically, asthma is often difficult to diagnose because of the non-specific symptoms that characterize the disease.(2) A physician may conduct a challenge study to measure lung function in order to diagnose asthma. Challenge studies may be referred to by a number of different names, including: Methacholine Challenge Test (MCT), Methacholine Inhalation Test, Bronchoprovocation Test, Histamine Challenge Test, and Histamine Inhalation Test.(3)
With the MCT, a physician attempts to trigger asthma symptoms by having the patient inhale the substance methacholine, which causes the airways to narrow in people with asthma.(1) After a spirometry test to determine baseline lung function, the patient is asked to breathe in a low dose of methacholine. The amount of the methacholine is gradually increased. When the lungs show a significant worsening in function (20 percent decrease in breathing ability) the test is complete and indicates a diagnosis of asthma.(3)
One of the recommended methacholine dosing schedules, published in the American Journal of Respiratory and Critical Care Medicine, is as follows: (100-mg vial of methacholine chloride and five-breath dosimeter protocol) E. 0.0625 mg/ml, D. 0.25 mg/ml, C. 1 mg/ml, B. 4 mg/ml, A. 16mg/ml.(4)
Methacholine challenge testing is most often considered when asthma is a serious possibility and traditional methods, most notably spirometry, have not been conclusive.4 “Symptoms that suggest asthma include wheezing, dyspnea, chest tightness, or cough in the following circumstances: (1) with exposure to cold air, (2) after exercise, (3) during respiratory infections, (4) following inhalant exposures in the workplace, and (5) after exposure to allergens and other asthma triggers. A history of such symptoms increases the pretest probability of asthma.”(4)
(1) The Mayo Clinic, Asthma: Steps in Testing and Diagnosis, https://www.mayoclinic.org/
(2) Sayeedi, I. MD, and Widrich, J. MD, National Center for Biotechnology Information, Methacholine Challenge Test, https://www.ncbi.nlm.nih.gov/
(3) American Thoracic Society, Patient Information Series, Lung Function Studies: Methacholine Challenge Test, https://www.lung.org/
(4) American Journal of Respiratory and Critical Care Medicine, Guidelines for Methacholine and Exercise Challenge Testing 1999, https://www.atsjournals.org/
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