LET Topical Anesthetic


LET gel


Edge Pharma is proud to provide LET topical anesthetic to hospital emergency departments, urgent care centers, pediatrician offices, and other qualified health care providers. LET Gel is a topical anesthetic consisting of Lidocaine, Epinephrine, and Tetracaine which is commonly applied to open wounds prior to suturing.

Our LET Gel is dispensed in convenient 3mL unit dose amber syringes.  Each dose is individually labeled to minimize the possibility of misadministration. Whether you are in charge of the inventory in a very busy emergency department or you have an independent pediatric practice that would like to keep a few doses on hand, Edge can meet your needs. As an FDA-Registered 503B Outsourcing Facility we are able to dispense LET Gel without requiring patient names.


LET Topical Gel 

Single-dose amber syringe for topical use, 3mL per syringe.

Storage: refrigerated

  • Lidocaine 4%
  • Epinephrine 0.05%
  • Tetracaine 0.5%



Principles of Office Anesthesia: Part II. Topical Anesthesia KUNDU, M.D., Scripps Clinic, San Diego, California. SURAJ ACHAR, M.D., University of California, San Diego, School of Medicine, La Jolla,California.Am Fam Physician. 2002 Jul 1;66(1):99102 https://www.aafp.org/

"Today, pain can be effectively alleviated for such procedures as cryotherapy, shave biopsy, and curettage of molluscum contagiosa. Procedures such as laceration repair, which at one time required the use of painful infiltrative anesthetics, can now be accomplished safely and comfortably with the use of topical anesthetics. An additional advantage of topical anesthetics in laceration repair is that wound margins are not distorted."

"For analgesia to nonintact skin, LET gel is generally preferred over TAC because of its superior safety record and cost-effectiveness."

"Both the solution and the gel have been safely used in children older than two years of age, and both forms are equally effective."


Literature Review


LET Gel Superior for Pain Control, Study Finds

Skin lacerations are a common cause of trips to the Emergency Department in the U.S., accounting for 8.2% of visits, which represents 7 to 9 million lacerations treated.(1) “Children are particularly susceptible to experiencing high levels of pain and anxiety during routine emergency procedures such as laceration repair.”(2)

A recent study compared the use of Lidocaine-epinephrine-tetracaine (LET) gel with EMLA plus Mepivacaine infiltration. The subjects were 59 children between the ages of 3 and 16 who presented at two medical centers. LET gel was administered to 37 children, 22 received EMLA plus Mepivacaine. “Pretreatment was significantly less painful in LET versus the local anesthetics group,” the study reported. Both groups showed similar efficacy in terms of procedure time, need for secondary infiltration, and infection rate. Pain was measured using the faces pain rating scale (visual analogue scale).(3)

The study concluded: “It appears that LET is superior to conventional anesthesia including Mepivacaine infiltration in the pediatric emergency departments. Pretreatment with LET is significantly less painful but equally effective. Hence, we recommend LET as a topical anesthetic in the pediatric emergency department.”(3)

(1) Otterness, K., Singer, A., Clinical and Experimental Emergency Medicine, Updates in Emergency Department Laceration Management, https://www.ncbi.nlm.nih.gov/
(2) Lambert, C., Goldman, R. M.D., Canada Family Physician, Pain Management for Children Needing Laceration Repair, https://pubmed.ncbi.nlm.nih.gov/
(3) Konigs, I., Wenskus, J. et. al., European Journal of Pediatric Surgery, Lidocaine-Epinephrine-Tetracaine Gel is More Efficient than Eutectic Mixture of Local Anesthetics and Mepivacaine Injection for Pain Control during Skin Repair in Children: A Prospective, Propensity Score Matched Two-Center Study, https://pubmed.ncbi.nlm.nih.gov/


Register To Order Online

We are currently licensed to sell to all US states except Alabama and Virginia. Our online system makes ordering quick and easy. Just submit the simple form below to setup an account with Edge. Medical, DEA, or hospital pharmacy licenses will be required to order LET topical anesthetic.

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